Fabrizio Montecucco, Cardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Researches, 64 Avenue Roseraie, 1211 Geneva, Switzerland, Tel.: +41 223827238, Fax: +41 223827245, E-mail:
Thromb Haemost. 2013 Sep;110(3):501-14. doi: 10.1160/TH13-03-0211. Epub 2013 Jun 6.
The pathogenesis of acute myocardial infarction is known to be mediated by systemic, intraplaque and myocardial inflammatory processes. Among different immune cell subsets, compelling evidence now indicates a pivotal role for neutrophils in acute coronary syndromes. Neutrophils infiltrate coronary plaques and the infarcted myocardium and mediate tissue damage by releasing matrix-degrading enzymes and reactive oxygen species. In addition, neutrophils are also involved in post-infarction adverse cardiac remodelling and neointima formation after angioplasty. The promising results obtained in preclinical modelswith pharmacological approaches interfering with neutrophil recruitment or function have confirmed the pathophysiological relevance of these immune cells in acute coronary syndromes and prompted further studies of these therapeutic interventions. This narrative review will provide an update on the role of neutrophils in acute myocardial infarction and on the pharmacological means that were devised to prevent neutrophil-mediated tissue damage and to reduce post-ischaemic outcomes.
急性心肌梗死的发病机制被认为是由系统性、斑块内和心肌炎症过程介导的。在不同的免疫细胞亚群中，现在有强有力的证据表明中性粒细胞在急性冠状动脉综合征中起关键作用。中性粒细胞浸润冠状动脉斑块和梗死心肌，并通过释放基质降解酶和活性氧物质介导组织损伤。此外，中性粒细胞还参与梗死后的心脏不良重构和血管成形术后的新生内膜形成。在药理学方法干预中性粒细胞募集或功能的临床前模型中获得的有希望的结果证实了这些免疫细胞在急性冠状动脉综合征中的病理生理相关性，并促使对这些治疗干预措施进行进一步研究。这篇叙述性综述将提供关于中性粒细胞在急性心肌梗死中的作用以及为预防中性粒细胞介导的组织损伤和减少缺血后结果而设计的药理学手段的最新信息。
