Sagol Department of Neurobiology, Center for Gene Manipulation in the Brain, University of Haifa, Mt. Carmel, Haifa 31905, Israel.
Neurobiol Learn Mem. 2013 Oct;105:100-6. doi: 10.1016/j.nlm.2013.04.015. Epub 2013 Jun 3.
One of the hallmarks of learning processes in any species studied so far is that they require intact protein synthesis machinery in order to consolidate memories. Interestingly, synaptic plasticity and consolidation processes share similar molecular mechanisms. In recent years, different laboratories have been studying regulation of translation machinery as a molecular entity underlying the consolidation process. Protein synthesis consists of three phases: initiation, elongation, and termination. The initiation step is considered the rate limiting step of protein synthesis. However, there is growing evidence that critical regulation of protein synthesis occurs at the elongation phase as well. Here, we focus on the eukaryotic elongation factor 2 (eEF2) pathway as a major regulator of protein synthesis, synaptic plasticity and memory consolidation.
学习过程的一个特点是，在目前研究过的任何物种中，它们都需要完整的蛋白质合成机制才能巩固记忆。有趣的是，突触可塑性和巩固过程具有相似的分子机制。近年来，不同的实验室一直在研究翻译机制的调节作为巩固过程的分子实体。蛋白质合成由三个阶段组成：起始、延伸和终止。起始步骤被认为是蛋白质合成的限速步骤。然而，越来越多的证据表明，蛋白质合成的关键调节也发生在延伸阶段。在这里，我们专注于真核延伸因子 2（eEF2）途径作为蛋白质合成、突触可塑性和记忆巩固的主要调节剂。
