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[17毫米圣犹达医疗Regent瓣膜主动脉瓣置换术的中长期临床结果及血流动力学评估]

[Mid-long-term clinical results and hemodynamic evaluation of aortic valve replacement with 17 mm St. Jude medical regent valve].

作者信息

Liu Yong, Zhang Er-Yong, Fang Zhi, Gu Jun, Qian Hong

机构信息

Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.

出版信息

Sichuan Da Xue Xue Bao Yi Xue Ban. 2013 Mar;44(2):316-8, 326.

Abstract

OBJECTIVE

To investigate the mid-long-term clinical results of aortic valve replacement with 17 mm St. Jude medical regent valve with hemodynamic evaluation including the measurement of effective orifice area, the occurrence of prosthesis-patient mismatch (PPM) and its affect on heart function.

METHODS

There were 44 patients accepted aortic valve replacement with 17 mm St. Jude medical regent valve because of small aortic annulus. Before the operation and during the postoperative follow-up, color doppler echocardiography was used to measure the hemodynamic parameters, such as left ventricular mass (LVmass), effective orifice area (EOA) and effective orifice area index (EOAI), etc.

RESULTS

Transthoracic echocardiographic data were obtained from 39 of 44 patients (88.6%) at 12-55 months after surgery. One (2.27%) died of heart failure in 1 year. According to the current standard of PPM (EOAI < or = 0.85 cm2/m2), 33 cases (82.1%) had PPM, 13 cases (30.8%) had severe PPM with an EOAI < or = 0.65 cm2/m2. After the operation, there were significant decreases in LVAo-PG (19 +/- 8) mmHg and left ventricular mass index (LVmass I) (86.6 +/- 23.3) g/m2 (P < 0.05). The assessment for physical capacity according to NYHA classification: 41 patients improved to class II or better and 2 patients improved to class III (P < 0.05).

CONCLUSION

The patients with small aortic annulus may obtain satisfactory clinical results after AVR with 17 mm St. Jude medical regent valve, PPM seems not affect the mid-long-term results.

摘要

目的

探讨采用17mm圣犹达医疗Regent瓣膜进行主动脉瓣置换术的中长期临床结果,并进行血流动力学评估,包括有效瓣口面积的测量、人工瓣膜-患者不匹配(PPM)的发生情况及其对心功能的影响。

方法

44例因主动脉瓣环小而接受17mm圣犹达医疗Regent瓣膜主动脉瓣置换术的患者。术前及术后随访期间,采用彩色多普勒超声心动图测量血流动力学参数,如左心室质量(LVmass)、有效瓣口面积(EOA)和有效瓣口面积指数(EOAI)等。

结果

44例患者中有39例(88.6%)在术后12 - 55个月获得经胸超声心动图数据。1例(2.27%)在1年内死于心力衰竭。根据目前PPM的标准(EOAI≤0.85cm²/m²),33例(82.1%)存在PPM,13例(30.8%)存在严重PPM,EOAI≤0.65cm²/m²。术后,左心室流出道压差(LVAo - PG)(19±8)mmHg和左心室质量指数(LVmass I)(86.6±23.3)g/m²显著降低(P<0.05)。根据纽约心脏协会(NYHA)分级对体力的评估:41例患者改善至Ⅱ级或更好,2例患者改善至Ⅲ级(P<0.05)。

结论

主动脉瓣环小的患者采用17mm圣犹达医疗Regent瓣膜进行主动脉瓣置换术后可能获得满意的临床结果,PPM似乎不影响中长期结果。

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