Laboratory of NF-κB Signaling, Institute of Molecular and Cell Biology (IMCB), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.
Trends Mol Med. 2013 Aug;19(8):487-500. doi: 10.1016/j.molmed.2013.05.001. Epub 2013 Jun 6.
Inflammation is indispensable for host homeostasis against invading pathogens and efficient wound healing upon tissue malfunction and has to be tightly controlled by various mechanisms to limit excess responses harmful to host tissues. A myriad of disease conditions ranging from type 2 diabetes (T2D) to neurodegenerative and cardiovascular disorders are now shown to progress due to persistent, unresolved inflammation in metabolic tissues such as adipose, liver, pancreas, muscle, and brain. However, their underlying mechanisms are incompletely understood. The actions of innate and adaptive immune cells in these ailments are increasingly appreciated so much so that a new research area called 'immunometabolism' has emerged. In this review, we will highlight the fundamental roles of various immune cells in adipose tissue during the initiation and progression of obesity-induced inflammation and discuss potential anti-inflammatory therapies from different mechanistic points of view.
炎症对于宿主对抗入侵病原体和组织功能障碍后的有效伤口愈合是必不可少的，但它必须通过各种机制来进行严格控制，以限制对宿主组织有害的过度反应。目前有大量疾病，从 2 型糖尿病（T2D）到神经退行性和心血管疾病，都表现为由于代谢组织（如脂肪、肝脏、胰腺、肌肉和大脑）中持续存在、未解决的炎症而进展。然而，其潜在机制尚不完全清楚。先天和适应性免疫细胞在这些疾病中的作用越来越受到重视，以至于出现了一个新的研究领域，称为“免疫代谢”。在这篇综述中，我们将强调各种免疫细胞在肥胖引起的炎症发生和发展过程中在脂肪组织中的基本作用，并从不同的机制角度讨论潜在的抗炎治疗方法。
