恒河猴运动皮层缺血性损伤后，细胞疗法有助于精细运动功能的恢复。
Recovery of fine motor performance after ischemic damage to motor cortex is facilitated by cell therapy in the rhesus monkey.
作者信息
Moore Tara L, Pessina Monica A, Finklestein Seth P, Kramer Brian C, Killiany Ronald J, Rosene Douglas L
机构信息
Department of Anatomy & Neurobiology, Boston University School of Medicine , Boston, MA , USA .
出版信息
Somatosens Mot Res. 2013 Dec;30(4):185-96. doi: 10.3109/08990220.2013.790806. Epub 2013 Jun 12.
Abstract
We investigated the efficacy on recovery of function following controlled cortical ischemia in the monkey of the investigational cell drug product, CNTO 0007. This drug contains a cellular component, human umbilical tissue-derived cells, in a proprietary thaw and inject formulation. Results demonstrate significantly better recovery of motor function in the treatment group with no difference between groups in the volume or surface area of ischemic damage, suggesting that the cells stimulated plasticity.
摘要
我们研究了研究性细胞药物产品CNTO 0007对猴子控制性皮质缺血后功能恢复的疗效。这种药物在一种专利的解冻和注射制剂中含有一种细胞成分，即人脐带组织衍生细胞。结果表明，治疗组的运动功能恢复明显更好，而缺血损伤的体积或表面积在各组之间没有差异，这表明这些细胞刺激了可塑性。
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本文引用的文献
1
Survival rate and life span of rhesus monkeys at the Yerkes regional primate research center.
Am J Primatol. 1988;15(3):263-273. doi: 10.1002/ajp.1350150308.
2
uPA and MMP-2 were involved in self-assembled network formation in a two dimensional co-culture model of bone marrow stromal cells and endothelial cells.
J Cell Biochem. 2013 Mar;114(3):650-7. doi: 10.1002/jcb.24407.
3
Emerging stem cell therapies: treatment, safety, and biology.
Stem Cells Int. 2012;2012:521343. doi: 10.1155/2012/521343. Epub 2012 Aug 2.
4
MRI detects brain reorganization after human umbilical tissue-derived cells (hUTC) treatment of stroke in rat.
PLoS One. 2012;7(8):e42845. doi: 10.1371/journal.pone.0042845. Epub 2012 Aug 10.
5
Autologous mesenchymal stem cells in chronic stroke.
Cerebrovasc Dis Extra. 2011 Jan-Dec;1(1):93-104. doi: 10.1159/000333381. Epub 2011 Dec 3.
6
Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation.
Lancet Neurol. 2012 Apr;11(4):369-80. doi: 10.1016/S1474-4422(12)70039-X. Epub 2012 Mar 19.
7
Therapeutic effect of human umbilical tissue-derived cell treatment in rats with experimental intracerebral hemorrhage.
Brain Res. 2012 Mar 20;1444:1-10. doi: 10.1016/j.brainres.2012.01.024. Epub 2012 Jan 20.
8
Heart disease and stroke statistics--2012 update: a report from the American Heart Association.
Circulation. 2012 Jan 3;125(1):e2-e220. doi: 10.1161/CIR.0b013e31823ac046. Epub 2011 Dec 15.
9
Investigational therapies for ischemic stroke: neuroprotection and neurorecovery.
Neurotherapeutics. 2011 Jul;8(3):434-51. doi: 10.1007/s13311-011-0040-6.
10
Umbilical cord blood cell transplantation after brain ischemia--from recovery of function to cellular mechanisms.
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