卡维地洛可恢复心肌梗死后大鼠的正常血压变异性。

Carvedilol recovers normal blood pressure variability in rats with myocardial infarction.

机构信息

Department of Physiological Sciences, Federal University of Espírito Santo, Av. Marechal Campos 1468, Maruípe, Vitória - ES, 29042-751, Brazil.

出版信息

Auton Neurosci. 2013 Oct;177(2):231-6. doi: 10.1016/j.autneu.2013.05.007. Epub 2013 Jun 10.

DOI:10.1016/j.autneu.2013.05.007

PMID:23759752

Abstract

BACKGROUND

The aim of this study was to investigate the effects of chronic treatment with carvedilol in blood pressure (BPV) and heart rate (HRV) variability of rats with myocardial infarction (MI).

METHODS

MI was produced in male rats by ligature of anterior interventricular branch of left coronary artery. Control rats were submitted to a sham surgery (SO). MI and SO rats were randomized to receive for 30 days placebo (Plac 0.5% metilcelulose) or carvedilol (Carv, 2mg/Kg body weight/day, drinking water): SO-Plac (N = 10), SO-Carv (N = 10), MI-Plac (N = 12), MI-Carv (N = 13). Blood pressure (BP) was directly recorded in the awake animals and BPV was determined, in time (variance, mmhg(2)) and frequency domains by the autoregressive method. Statistical significance was set in P<0.05. Data are median and interquartile range.

RESULTS

No significant changes in HRV was observed in MI rats, while BPV showed significant decreasing of blood pressure variance (SO-Plac = 42.08 (39.21) mmHg(2) vs. MI-Plac = 21.67 (12.58) mmHg(2), P<0.05), reversed by the Carv treatment (MI-Plac = 21.67 (12.58) vs. MI-Carv = 38.64 (29.25), P<0.05). In the frequency domain analyses, MI reduced absolute and normalized LF component (LF (mmHg(2)): SO-Plac = 8.98 (14.84) vs. MI-Plac = 2.08 (4.84), P<0.05; LF(nu): SO-Plac = 79.48 (45.03) nu vs. MI-Plac = 24.25 (40.67) nu, P<0.05) and increased the normalized HF component of the BPV (SO-Plac = 20.51 (39.18) vs. MI-Plac = 60.51 (39.73). Carv treatment significantly attenuated the LF component fall.

CONCLUSION

Chronic treatment with carvedilol restored the variance of BPV altered by the MI.

摘要

背景

本研究旨在探讨卡维地洛对心肌梗死（MI）大鼠血压（BPV）和心率变异性（HRV）的慢性治疗作用。

方法

通过结扎左冠状动脉前降支在雄性大鼠中产生 MI。对照大鼠接受假手术（SO）。MI 和 SO 大鼠被随机分为 30 天安慰剂（Plac 0.5%甲基纤维素）或卡维地洛（Carv，2mg/Kg 体重/天，饮用水）：SO-Plac（N=10），SO-Carv（N=10），MI-Plac（N=12），MI-Carv（N=13）。在清醒动物中直接记录血压（BP），并通过自回归法在时间（方差，mmHg(2))和频率域中确定 BPV。P<0.05 为具有统计学意义。数据为中位数和四分位距。

结果

MI 大鼠的 HRV 无明显变化，而 BPV 显示血压方差明显降低（SO-Plac=42.08（39.21）mmHg(2)vs.MI-Plac=21.67（12.58）mmHg(2)，P<0.05），卡维地洛治疗后逆转（MI-Plac=21.67（12.58）vs.MI-Carv=38.64（29.25），P<0.05）。在频域分析中，MI 降低了绝对和归一化 LF 成分（LF（mmHg(2))：SO-Plac=8.98（14.84）vs.MI-Plac=2.08（4.84），P<0.05；LF(nu)：SO-Plac=79.48（45.03）nu vs.MI-Plac=24.25（40.67）nu，P<0.05），并增加了 BPV 的归一化 HF 成分（SO-Plac=20.51（39.18）vs.MI-Plac=60.51（39.73）。卡维地洛治疗显著减弱了 LF 成分的下降。