酒精相关性周围神经病的实验模型。
Experimental model of alcohol-related peripheral neuropathy.
机构信息
Department of Neurology, Warren Alpert School of Medicine, Rhode Island Hospital, Brown University, Suite 555, 2 Dudley Street, Providence, Rhode Island 02905, USA.
出版信息
Muscle Nerve. 2013 Aug;48(2):204-11. doi: 10.1002/mus.23744. Epub 2013 Jun 13.
INTRODUCTION
The aim of this work was to determine the effect of chronic alcohol exposure on peripheral nerves in a nutritionally balanced rat model of alcoholism.
METHODS
Three different strains of adult male rats were pair-fed for 8 weeks with isocaloric liquid diets containing 0% or 37% ethanol. Nerve conduction studies (NCS) were performed. Peripheral nerve and muscle were examined histologically with morphometrics.
RESULTS
Ethanol exposure significantly slowed velocity in tibial and fibular nerves, but not in the plantar nerve in all 3 strains. Studies of the sciatic nerve revealed decreased fiber diameters and increased regenerative sprouts in peripheral nerves. There was muscle denervation of ethanol-exposed rats in all 3 strains.
CONCLUSIONS
Chronic ethanol exposure caused a polyneuropathy characterized by axonal degeneration despite adequate nutrition. These results suggest that ethanol exposure has direct neurotoxic effects on peripheral nerves. This model may be useful in understanding the underlying mechanism(s) of alcohol-related peripheral neuropathy.
简介
本研究旨在通过一种营养均衡的酒精中毒大鼠模型，确定慢性酒精暴露对周围神经的影响。
方法
将三种不同品系的成年雄性大鼠进行为期 8 周的等热量液体饮食喂养，其中含有 0%或 37%乙醇。进行神经传导研究（NCS）。用形态计量学方法对周围神经和肌肉进行组织学检查。
结果
尽管营养充足，但在所有 3 种品系中，酒精暴露均显著减慢了胫神经和腓神经的速度，但对足底神经没有影响。对坐骨神经的研究显示，外周神经中的纤维直径减小，再生芽增多。在所有 3 种品系中，暴露于酒精的大鼠均出现肌肉去神经支配。
结论
尽管营养充足，慢性乙醇暴露仍可导致多发性神经病，表现为轴突变性。这些结果表明，乙醇暴露对周围神经具有直接的神经毒性作用。该模型可能有助于理解酒精相关周围神经病变的潜在机制。
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