Bist Sampan S, Bisht Manisha, Purohit Jagdish P
Department of ENT & Pharmacology, Himalayan Institute of Medical Sciences, Dehradun 248140, India.
ISRN Otolaryngol. 2012 Nov 19;2012:404075. doi: 10.5402/2012/404075. Print 2012.
Background. The objective of this prospective study was to evaluate the clinical profile, microbiological flora and radiological features in primary atrophic rhinitis patients and to identify their association with the etiology of primary atrophic rhinitis. Study design. Prospective case study. Materials and methods. Patients with primary atrophic rhinitis over a two years period were included in the study. Complete blood count, total protein and microbiological analysis from nasal swab were done to evaluate iron deficiency anemia, nutritional status and identification of the pathogenic bacteria respectively. Radiological evaluation was done to study the radiological features of primary atrophic rhinitis. Observations. Ninety cases of primary atrophic rhinitis were studied. The most common symptom was nasal crusting. Nasal crust, odour and atrophy of mucosa were the most consistent finding. Nasal myiasis was found in 26.6% cases. The nasal mucociliary clearance time was markedly increased. On investigation there were low value of hemoglobin and total protein in 46.6% and 25.5% patients, respectively. Pseudomonas aeruginosa (37%) was the commonest organism isolated from culture. On radiological evaluation evidence of different grade of sinusitis was seen in 87.7% case. Conclusion. The present study suggested that certain bacterial infections, anemia, poor nutrition and hereditary factor may contribute significantly to the etiology of primary atrophic rhinitis.
背景。本前瞻性研究的目的是评估原发性萎缩性鼻炎患者的临床特征、微生物菌群和放射学特征,并确定它们与原发性萎缩性鼻炎病因的关联。研究设计。前瞻性病例研究。材料与方法。纳入研究的是在两年期间患有原发性萎缩性鼻炎的患者。分别进行全血细胞计数、总蛋白检测以及鼻拭子微生物分析,以评估缺铁性贫血、营养状况并鉴定病原菌。进行放射学评估以研究原发性萎缩性鼻炎的放射学特征。观察结果。对90例原发性萎缩性鼻炎患者进行了研究。最常见的症状是鼻结痂。鼻痂、气味和黏膜萎缩是最一致的表现。26.6%的病例发现有鼻蝇蛆病。鼻黏膜纤毛清除时间明显延长。调查发现,分别有46.6%和25.5%的患者血红蛋白和总蛋白值较低。铜绿假单胞菌(37%)是培养分离出的最常见病原体。放射学评估显示,87.7%的病例有不同程度鼻窦炎的证据。结论。本研究表明,某些细菌感染、贫血、营养不良和遗传因素可能对原发性萎缩性鼻炎的病因有显著影响。