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[雷安贝林和细胞黄素对急性烧伤病程及结局影响的实验评估]

[Experimental evaluation of reamberin and cytoflavin effects on the course and outcome of acute burn injury].

作者信息

Zinov'ev E V, Nesterov Iu V, Lagvilava T O

出版信息

Eksp Klin Farmakol. 2013;76(4):39-44.

Abstract

Survival rate, average life expectancy of victims, parameters of the acid - base balance, gas composition of blood, and morphological structure of internal organs have been studied in acute experiments on a group of 120 rats with burn injury of IIIB degree (20% of body surface) against early introduction of antihypoxants reamberin and cytoflavin. It is established that the introduction of antihypoxants reliably prevents the development of typical pathologic processes and hypoxemia, reduces expressiveness of organ dysfunction and extent of mophological changes in internal organs, and increases 1.5 - 2.5 times the survival rate of heavily damaged animals in the acute period of burn injury.

摘要

在一组120只III B度烧伤(体表20%)大鼠的急性实验中,研究了存活率、受害者平均预期寿命、酸碱平衡参数、血液气体成分以及内脏器官的形态结构,这些实验针对早期引入抗缺氧剂雷姆巴林和细胞黄素的情况。结果表明,引入抗缺氧剂能可靠地预防典型病理过程和低氧血症的发展,降低器官功能障碍的表现程度和内脏器官形态变化的程度,并使重度损伤动物在烧伤急性期的存活率提高1.5至2.5倍。

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