School of Health and Population Sciences, University of Birmingham, UK; ePrescribing Research Team, University Hospital Birmingham, Birmingham, UK; Institute of Digital Healthcare, University of Warwick, UK; Warwick Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals of Coventry and Warwickshire, Coventry, UK.
J Diabetes Complications. 2013 Sep-Oct;27(5):454-8. doi: 10.1016/j.jdiacomp.2013.05.003. Epub 2013 Jun 15.
We aimed to determine whether in-patient mortality and length of stay were greater in diabetes patients with foot disease compared to those without foot disease.
Retrospective data analysis of admissions over four years (2007-2010) to University Hospital Birmingham. Based on discharge diagnostic codes we grouped admissions into those 1) with amputation, 2) with foot disease and 3) without foot disease. Inpatient mortality and length of stay were compared between the three groups, adjusting for confounders.
We identified 25,118 admissions with diabetes of which 1149 admissions (4.6%) had foot disease and another 195 (0.8%) had a code for lower limb amputation. When compared to those without foot disease the adjusted odds ratio for inpatient mortality was 1.31 (95% CI 1.04-1.65 P=0.02) in the foot disease group, and 1.02 (95% CI 0.56-1.85 P=0.95) in the amputation group; and the adjusted relative ratio for length of stay was 2.01 (95 CI 1.86-2.16 P<0.001) in the foot disease group and 3.08 (95% CI 2.60-3.65 P<0.001) in the amputation group.
Foot disease in hospitalised patients with diabetes is associated with increased length of stay and inpatient mortality. Our study adds to evidence on excess mortality associated with diabetic foot disease and to evidence on excess mortality observed in people with diabetes admitted to hospitals.
本研究旨在比较糖尿病合并足部疾病患者与无足部疾病患者的住院病死率和住院时间,以明确糖尿病足部疾病患者的住院病死率和住院时间是否更高。
回顾性分析了四年间(2007-2010 年)伯明翰大学医院的住院患者数据。根据出院诊断编码,我们将患者分为三组:1)截肢,2)足部疾病,3)无足部疾病。在调整混杂因素后,比较三组患者的住院病死率和住院时间。
我们共纳入了 25118 例糖尿病住院患者,其中 1149 例(4.6%)患有足部疾病,195 例(0.8%)患有下肢截肢编码。与无足部疾病的患者相比,足部疾病组的住院病死率调整比值比为 1.31(95%可信区间 1.04-1.65,P=0.02),截肢组为 1.02(95%可信区间 0.56-1.85,P=0.95);足部疾病组的住院时间相对比值比为 2.01(95%可信区间 1.86-2.16,P<0.001),截肢组为 3.08(95%可信区间 2.60-3.65,P<0.001)。
糖尿病住院患者的足部疾病与住院时间延长和住院病死率增加相关。本研究进一步证实了糖尿病足部疾病与病死率增加相关,也进一步证实了糖尿病患者住院后病死率增加的情况。