ω-3补充剂对2型糖尿病患者抗氧化能力的影响。
The effect of omega-3 supplements on antioxidant capacity in patients with type 2 diabetes.
作者信息
Hajianfar Hossein, Paknahad Zamzam, Bahonar Ahmad
机构信息
Food Security Research Center, Faculty of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Int J Prev Med. 2013 May;4(Suppl 2):S234-8.
BACKGROUND
Diabetes is one of the most common chronic diseases in which antioxidant capacity changes. Omega-3 fatty acids have extensive biological effects including their advantage on lipoprotein metabolism, platelet function, cytokine production, clotting, fibrinolysis, and inflammatory factors. This study aimed to investigate the effect of omega-3 fatty acid supplements on antioxidant capacity in patients with type 2 diabetes.
METHODS
This clinical trial enrolled 71 women with type 2 diabetes in two case (treated with omega-3 capsules) and control (treated with placebo) groups. In the first stage, participants filled out a demographics questionnaire including age, height, weight, waist circumference, and hip circumference.Their blood sample was taken to evaluate glycosylated hemoglobin and antioxidant capacity. Then the case group received intervention for 8 weeks and weight, waist circumference, and hip circumference were measured and a blood sample was taken again. The data were analyzed using SPSS 18 software.
RESULTS
The mean difference of antioxidant capacity before and after intervention was significant (P < 0.001). Antioxidant capacity increased in the case group and reduced in the control group.
CONCLUSIONS
With regard to the results of the present study, patients with type 2 diabetes increase their antioxidant capacity, enhance their antioxidant defense system, and probably prevent diabetes complications and related disease progress by taking omega-3 supplements.
背景
糖尿病是抗氧化能力发生变化的最常见慢性病之一。ω-3脂肪酸具有广泛的生物学效应，包括对脂蛋白代谢、血小板功能、细胞因子产生、凝血、纤维蛋白溶解和炎症因子的有益作用。本研究旨在探讨补充ω-3脂肪酸对2型糖尿病患者抗氧化能力的影响。
方法
本临床试验纳入71名2型糖尿病女性患者，分为两组，即病例组（服用ω-3胶囊）和对照组（服用安慰剂）。在第一阶段，参与者填写一份人口统计学调查问卷，包括年龄、身高、体重、腰围和臀围。采集她们的血样以评估糖化血红蛋白和抗氧化能力。然后病例组接受8周干预，测量体重、腰围和臀围，并再次采集血样。数据使用SPSS 18软件进行分析。
结果
干预前后抗氧化能力的平均差异具有统计学意义（P < 0.001）。病例组抗氧化能力增加，而对照组降低。
结论
根据本研究结果，2型糖尿病患者通过服用ω-3补充剂可提高其抗氧化能力，增强抗氧化防御系统，并可能预防糖尿病并发症及相关疾病进展。
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