Kellokumpu-Lehtinen Pirkko, Tammela Teuvo
Tampereen yliopisto, lääketieteen yksikköo ja TAYS.
Duodecim. 2013;129(9):923-30.
Several effective drugs have become available for prostate cancer therapy, which are being used after the development of castration resistance and studied already at an earlier stage of prostate cancer therapy. Novel hormonally acting drugs include degarelix, enzalutamide and abiraterone. Cytotoxic agents that have proven effective in studies include the docetaxel derivative cabazitaxel, denosumab in the prevention of complications caused by bone metastases, and radium-233 chloride as treatment for bone metastases. The optimal sequence of administration of the novel drugs as well as combining them are subject to intensive research.
几种有效的药物已可用于前列腺癌治疗,这些药物在去势抵抗出现后使用,并且在前列腺癌治疗的早期阶段就已进行研究。新型激素作用药物包括地加瑞克、恩杂鲁胺和阿比特龙。在研究中已证明有效的细胞毒性药物包括多西他赛衍生物卡巴他赛、用于预防骨转移引起的并发症的地诺单抗以及作为骨转移治疗药物的氯化镭-233。新型药物的最佳给药顺序以及联合使用正在进行深入研究。