Ingman S R, Lawson I R, Pierpaoli P G, Blake P
J Am Geriatr Soc. 1975 Jul;23(7):309-16. doi: 10.1111/j.1532-5415.1975.tb00219.x.
The prescription and administration of drugs (especially of the neuroactive class) was observed in 131 patients in an extended care facility. The average number of neuroactive drugs prescribed (2.1) was distinctly different from the average number administered (1.3) because of the large number of pro re nata (prn) prescriptions. More neuroactive substances were prescribed for patients with superior mentation and minimal physical disability; the difference between low and high groups was 1.7 (mentation) and 2.8 (physical status). The most common neuroactive drugs prescribed were: 1) analgesics, 2) major tranquilizers, and 3) hypnotics. Questionable prescribing practices were demonstrated by the fact that 30 patients had prescriptions for 38 "not-recommended"drugs; 23 of these prescriptions were for propoxyphene compound. After requiring physicians to rewrite drug orders every thirty days, a survey made ten months later showed that there was a decline (0.8) in the number of drugs prescribed per patient and a slight increase (0.45) in the number of drugs administered. Professional drug surveillance is crucial for improving the therapeutic process. At least two modifications of current prescribing practices are recommended: 1) a record should always be made of the precise condition(s) under which a drug prescribed "prn" is to be administered; and 2) a strong effort should be made to reduce the total number of drug prescriptions. The results of this survey suggest that certain procedural matters necessitating change are not in themselves the most substantive factors in improvement. Present "third party" review mechanisms likely will not ameliorate the current situation. It will be necessary to implement complex organizational changes in most extended care facilities.
在一家长期护理机构中,对131名患者的药物处方和用药情况(尤其是神经活性类药物)进行了观察。由于大量的必要时(prn)处方,所开神经活性药物的平均数量(2.1种)与用药的平均数量(1.3种)明显不同。精神状态较好且身体残疾程度较轻的患者所开的神经活性物质更多;低分组和高分组之间的差异在精神状态方面为1.7,在身体状况方面为2.8。所开最常见的神经活性药物为:1)镇痛药,2)主要镇静剂,3)催眠药。30名患者有38种“不推荐”药物的处方,这一事实表明存在可疑的处方行为;其中23张处方是丙氧芬复方制剂。在要求医生每30天重新开具药物医嘱后,10个月后进行的一项调查显示,每位患者所开药物数量有所下降(0.8种),用药数量略有增加(0.45种)。专业的药物监测对于改善治疗过程至关重要。建议至少对当前的处方做法进行两项改进:1)对于“必要时”开具的药物,应始终记录其具体的用药条件;2)应大力努力减少药物处方的总数。本次调查结果表明,某些需要改变的程序事项本身并非改善的最实质性因素。目前的“第三方”审查机制可能无法改善当前状况。在大多数长期护理机构中,有必要实施复杂的组织变革。