预防胃肠病学中免疫抑制药物引起的感染。
Prevention of infection caused by immunosuppressive drugs in gastroenterology.
机构信息
Division of Gastroenterology, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
出版信息
Ther Adv Chronic Dis. 2013 Jul;4(4):167-85. doi: 10.1177/2040622313485275.
Abstract
Immunosuppressive therapy is frequently used to treat gastrointestinal diseases such as inflammatory bowel disease, autoimmune hepatitis, IgG4-related disease (autoimmune pancreatitis and sclerosing cholangitis) and in the post-transplantation setting. These drugs interfere with the immune system. The main safety concern with their use is the risk of infections. Certain infections can be prevented or their impact minimized. Physicians must adopt preventative strategies and should have a high degree of suspicion to recognize infections early and treat appropriately. This article reviews the risk factors for infections, the mechanism of action of immunosuppressive therapy and proposes preventive strategies.
摘要
免疫抑制疗法常用于治疗胃肠道疾病，如炎症性肠病、自身免疫性肝炎、IgG4 相关疾病（自身免疫性胰腺炎和硬化性胆管炎）以及移植后。这些药物会干扰免疫系统。使用它们的主要安全问题是感染的风险。某些感染可以预防或使其影响最小化。医生必须采取预防策略，并高度怀疑感染，以便及早识别和适当治疗。本文回顾了感染的危险因素、免疫抑制治疗的作用机制，并提出了预防策略。
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