Oct 转录因子在发育和干细胞中的作用：见解与机制。
Oct transcription factors in development and stem cells: insights and mechanisms.
机构信息
Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
出版信息
Development. 2013 Jul;140(14):2857-66. doi: 10.1242/dev.095927.
Abstract
The POU domain family of transcription factors regulates developmental processes ranging from specification of the early embryo to terminal differentiation. About half of these factors display substantial affinity for an 8 bp DNA site termed the octamer motif, and are hence known as Oct proteins. Oct4 (Pou5f1) is a well-known Oct factor, but there are other Oct proteins with varied and essential roles in development. This Primer outlines our current understanding of Oct proteins and the regulatory mechanisms that govern their role in developmental processes and concludes with the assertion that more investigation into their developmental functions is needed.
摘要
POU 结构域转录因子家族调节从早期胚胎特化到终末分化的发育过程。这些因子中约有一半对称为八聚体基序的 8bp DNA 位点具有显著亲和力，因此被称为 Oct 蛋白。Oct4（Pou5f1）是一种众所周知的 Oct 因子，但还有其他 Oct 蛋白在发育中具有不同且重要的作用。本专题概述了我们目前对 Oct 蛋白的理解，以及调控其在发育过程中作用的机制，并得出结论，需要进一步研究它们在发育中的功能。
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