Department of Psychiatry and Psychotherapy, Medical Faculty, University of Leipzig, Semmelweisstraße 10, 04103 Leipzig, Germany.
Eur Cytokine Netw. 2013 Jun;24(2):97-103. doi: 10.1684/ecn.2013.0338.
Stress-induced cytokine changes may be the link between stress and the pathogenesis of psychiatric disorders such as depression, and organic diseases such as infections, autoimmune diseases and cancer. We tested the effect of stress on interleukin (IL)-2, IL-4, IL-6, IL-10, IL-22, tumour necrosis factor (TNF)-α and interferon (IFN)-γ serum levels in male Wistar rats. Rats underwent either acute stress by forced swimming (N = 8), chronic restraint stress (N = 8), or were not subjected to any stress (N = 8). IL-2 serum levels were significantly higher in forced swimming, but not in restraint stress rats, compared to non-stressed rats. IL-4, IL-6, IL-10 and TNF-α levels were higher in both forced swimming and restraint stress compared to non-stressed rats. IFN-γ production was significantly decreased by restraint stress, but not by forced swimming. IL-22 was not affected significantly by either stress condition. Alterations in the pro-inflammatory cytokines IL-6 and TNF-α may indicate a pathophysiological pathway from acute and chronic stress to the development of depression. Changes in IL-4 and IL-10 may link acute and chronic stress to autoimmune disorders, allergies or cancer. The reported changes in IFN-γ could provide an explanation for the higher susceptibility to infection seen in life periods associated with sustained levels of stress.
应激诱导的细胞因子变化可能是应激与精神障碍（如抑郁症）和器质性疾病（如感染、自身免疫性疾病和癌症）发病机制之间的联系。我们检测了应激对雄性 Wistar 大鼠白细胞介素（IL）-2、IL-4、IL-6、IL-10、IL-22、肿瘤坏死因子（TNF）-α和干扰素（IFN）-γ血清水平的影响。大鼠经历急性强迫游泳应激（N=8）、慢性束缚应激（N=8）或未经受任何应激（N=8）。与非应激大鼠相比，强迫游泳大鼠的血清 IL-2 水平显著升高，但束缚应激大鼠的 IL-2 水平没有升高。与非应激大鼠相比，强迫游泳和束缚应激大鼠的 IL-4、IL-6、IL-10 和 TNF-α 水平均升高。束缚应激显著降低 IFN-γ 的产生，但强迫游泳没有。IL-22 不受两种应激条件的显著影响。促炎细胞因子 IL-6 和 TNF-α 的改变可能表明从急性和慢性应激到抑郁症发展的病理生理途径。IL-4 和 IL-10 的改变可能将急性和慢性应激与自身免疫性疾病、过敏或癌症联系起来。报告的 IFN-γ 变化可能解释了与持续应激水平相关的生命阶段中更高的感染易感性。
