2,4-二羟基-9-苯基-1H-菲并-1-酮的自由基清除能力：一种功能基排除方法。

Radical scavenging capacity of 2,4-dihydroxy-9-phenyl-1H-phenalen-1-one: a functional group exclusion approach.

机构信息

Instituto de Química, Síntesis y Biosíntesis de Metabolitos Naturales, Universidad de Antioquia, A.A 1226, Medellín, Colombia.

出版信息

Org Lett. 2013 Jul 19;15(14):3542-5. doi: 10.1021/ol400384z. Epub 2013 Jul 8.

DOI:10.1021/ol400384z

PMID:23834597

Abstract

2,4-Dihydroxy-9-phenyl-1H-phenalen-1-one (4-hydroxyanigorufone, 1), a compound isolated from Anigozanthos flavidus and Monochoria elata, displayed a high radical scavenging capacity in the ORAC assay. A systematic approach was adopted in order to explore the effect of each functional group. H-Atom transfer from the phenolic hydroxyl, a captodative effect from the hydroxy ketone, and the presumed involvement of the phenyl ring in the termination step of the radical reaction were disclosed as relevant features of this type of antioxidant.

摘要

2,4-二羟基-9-苯基-1H-菲并[9,10-c]色烯-1-酮（4-羟基安哥拉紫檀素，1）是从 Anigozanthos flavidus 和 Monochoria elata 中分离得到的一种化合物，在 ORAC 测定中显示出很高的自由基清除能力。为了探索每个官能团的影响，采用了系统的方法。从酚羟基转移 H 原子、羟基酮的捕获效应以及假定苯基环参与自由基反应的终止步骤，被揭示为这种类型的抗氧化剂的相关特征。