Department of Molecular and Comparative Pathobiology, The Johns Hopkins University Baltimore, MD 21205, USA.
Am J Cancer Res. 2013 Jun 20;3(3):240-50. Print 2013.
Colorectal cancer (CRC) is the third leading cause of cancer-related death in the United States, with the number of affected people increasing. There are many risk factors that increase CRC risk, including family or personal history of CRC, smoking, consumption of red meat, obesity, and alcohol consumption. Conversely, increased screening, maintaining healthy body weight, not smoking, and limiting intake of red meat are all associated with reduced CRC morbidity and mortality. Mouse models of CRC were first used in 1928 and have played an important role in understanding CRC biology and treatment and have long been instrumental in clarifying the pathobiology of CRC formation and inhibition. This review focuses on advancements in modeling CRC in mice.
结直肠癌（CRC）是美国癌症相关死亡的第三大主要原因，且患病人数呈上升趋势。许多危险因素会增加 CRC 的风险，包括结直肠癌家族史或个人史、吸烟、食用红肉、肥胖和饮酒。相反，增加筛查、保持健康的体重、不吸烟和限制摄入红肉都与降低 CRC 的发病率和死亡率有关。1928 年首次在小鼠中使用 CRC 模型，这些模型在了解 CRC 生物学和治疗方面发挥了重要作用，并长期以来一直有助于阐明 CRC 形成和抑制的病理生物学。本综述重点介绍了在小鼠中建立 CRC 模型的进展。
