美国的背痛、中轴型脊柱关节炎和 HLA-B27 的流行病学。
The epidemiology of back pain, axial spondyloarthritis and HLA-B27 in the United States.
机构信息
Division of Rheumatology, The University of Texas Health Science Center, Houston, Texas 77030, USA.
出版信息
Am J Med Sci. 2013 Jun;345(6):431-6. doi: 10.1097/maj.0b013e318294457f.
Abstract
The concept of inflammatory back pain (IBP) evolved in the 1970s, coincident with the discovery of the HLA-B27 association with ankylosing spondylitis (AS), leading to the development of criteria to determine the presence of IBP. The concept of IBP and it relationship with AS and axial spondyloarthritis (AxSpA) has further evolved, and an instrument developed (the Spondylitis Association of America Back Pain Tool), which was further modified and field tested for use in the 2009 to 2010 National Health and Nutrition Examination Survey (NHANES). This has shown the frequency of chronic back pain to have risen to 19.4%, with nearly one third having IBP. The prevalence of AxSpA has been defined at 1.0% to 1.4% and AS at 0.52% to 0.55%. The national prevalence of HLA-B27 in the United States is 6.1%, and intriguing data from NHANES 2009 suggest a decreasing frequency with increasing age. From this arise new questions and a work agenda ahead.
摘要
炎症性背痛（IBP）的概念出现在 20 世纪 70 年代，与 HLA-B27 与强直性脊柱炎（AS）的关联同时发现，这导致了确定 IBP 存在的标准的发展。IBP 的概念及其与 AS 和轴性脊柱关节炎（AxSpA）的关系进一步发展，开发了一种仪器（美国强直性脊柱炎协会背痛工具），该仪器进一步修改并在 2009 年至 2010 年全国健康和营养调查（NHANES）中进行了现场测试。这表明慢性背痛的频率已上升到 19.4%，近三分之一的人有 IBP。AxSpA 的患病率定义为 1.0%至 1.4%，AS 为 0.52%至 0.55%。美国 HLA-B27 的全国流行率为 6.1%，来自 NHANES 2009 的有趣数据表明，随着年龄的增长，其频率呈下降趋势。由此产生了新的问题和未来的工作议程。
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