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膝关节软骨移植术后恢复运动生活方式。

Return to an athletic lifestyle after osteochondral allograft transplantation of the knee.

机构信息

Department of Orthopaedic Surgery, Tripler Army Medical Center, 1 Jarrett White Road, Honolulu, HI 96859, USA.

出版信息

Am J Sports Med. 2013 Sep;41(9):2083-9. doi: 10.1177/0363546513494355. Epub 2013 Jul 10.

Abstract

BACKGROUND

Osteochondral allograft transplantation (OATS) is a treatment option that provides the ability to restore large areas of hyaline cartilage anatomy and structure without donor site morbidity and promising results have been reported in returning patients to some previous activities. However, no study has reported on the durability of return to activity in a setting where it is an occupational requirement.

HYPOTHESIS

Osteochondral allograft transplantation is less successful in returning patients to activity in a population in which physical fitness is a job requirement as opposed to a recreational goal.

STUDY DESIGN

Case series; Level of evidence, 4.

METHODS

A retrospective review was conducted of 38 consecutive OATS procedures performed at a single military institution by 1 of 4 sports medicine fellowship-trained orthopaedic surgeons. All patients were on active duty at the time of the index procedure, and data were collected on demographics, return to duty, Knee Injury and Osteoarthritis Outcome Score (KOOS), and ultimate effect on military duty. Success was defined as the ability to return to the preinjury military occupational specialty (MOS) with no duty-limiting restrictions.

RESULTS

The mean lesion size treated was 487.0 ± 178.7 mm(2). The overall rate of return to full duty was 28.9% (11/38). An additional 28.9% (11/38) were able to return to limited activity with permanent duty modifications. An alarming 42.1% (16/38) were unable to return to military activity because of their operative knee. When analyzed for return to sport, only 5.3% (2/38) of patients were able to return to their preinjury level. Eleven patients underwent concomitant procedures. Statistical power was maintained by analyzing data in aggregate for cases with versus without concomitant procedures. When the 11 undergoing concomitant procedures were removed from the data set, the rate of return to full activity was 33.3% (9/27), with 22.3% (6/27) returning to limited activity and 44.4% (12/27) unable to return to activity. In this subset, 7.4% (2/27) were able to return to a preinjury level of sport. The KOOS values were significantly higher in the full activity group when compared with the limited and no activity groups (P < .01). Branch of service was a significant predictor of outcome, with Marine Corps and Navy service members more likely to return to full activity compared with Army and Air Force members. A MOS of combat arms was a significant predictor of a poor outcome. All patients demonstrated postoperative healing of their grafts as documented in their medical chart, and no patient in the series required revision for problems with graft incorporation.

CONCLUSION

Osteochondral allograft transplantation for the treatment of large chondral defects in the knee met with disappointing results in an active-duty population and was even less reliable in returning this population to preinjury sport levels. Branch of service and occupational type predicted the return to duty, but other traditional predictors of outcome such as rank and years of service did not. The presence of concomitant procedures did not have an effect on outcome with respect to activity or sport level with the numbers available for analysis.

摘要

背景

骨软骨同种异体移植(OATS)是一种治疗选择,它能够恢复透明软骨解剖结构和结构,而不会产生供体部位的发病率,并且在使患者恢复到某些先前活动方面已经取得了有希望的结果。然而,尚无研究报告在职业要求的情况下,活动回归的持久性。

假设

与作为娱乐目标相比,在身体素质是工作要求的人群中,骨软骨同种异体移植使患者恢复活动的成功率较低。

研究设计

病例系列;证据水平,4 级。

方法

对 1 名运动医学研究员骨科医生在一家军事机构进行的 38 例连续 OATS 手术进行了回顾性研究。所有患者在索引手术时均在现役,收集了人口统计学,返回工作,膝关节损伤和骨关节炎结果评分(KOOS)以及对军事任务的最终影响的数据。成功的定义是能够返回受伤前的军事职业专业(MOS),而没有限制工作的限制。

结果

治疗的平均病变大小为 487.0 ± 178.7mm²。总体恢复全部工作的比例为 28.9%(38 例中有 11 例)。另外 28.9%(38 例中有 11 例)能够通过永久性工作修改来恢复有限的活动。令人震惊的是,由于他们的手术膝盖,有 42.1%(38 例中有 16 例)无法恢复军事活动。在分析重返运动时,只有 5.3%(38 例中有 2 例)的患者能够恢复到受伤前的水平。有 11 例患者同时进行了其他手术。通过对有或没有同时进行的手术的病例进行汇总分析,保持了统计能力。当从数据集中删除同时进行的 11 例手术时,恢复全部活动的比例为 33.3%(27 例中有 9 例),22.3%(27 例中有 6 例)恢复到有限的活动,而 44.4%(27 例中有 12 例)无法恢复活动。在这一组中,有 7.4%(27 例中有 2 例)能够恢复到受伤前的运动水平。与有限活动和无活动组相比,KOOS 值在全部活动组中明显更高(P <.01)。军种是结果的重要预测因素,与陆军和空军相比,海军陆战队和海军的成员更有可能恢复全部活动。战斗兵种的 MOS 是预后不良的重要预测因素。所有患者的移植物均在其病历中记录了术后愈合,并且该系列中没有患者因移植物植入问题而需要进行修订。

结论

在现役人群中,用于治疗膝关节大软骨缺损的骨软骨同种异体移植的结果令人失望,甚至在使该人群恢复到受伤前的运动水平方面更为不可靠。军种和职业类型预测了回归工作,但其他传统的预后预测因素,如军衔和服役年限,并没有。在可分析的数量范围内,同时进行的手术对活动或运动水平的结果没有影响。

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