Institute for Stem Cell Biology and Regenerative Medicine, National Centre for Biological Sciences (TIFR), Bellary Road, Bangalore 560065, India.
Nat Rev Cancer. 2013 Aug;13(8):585-95. doi: 10.1038/nrc3556. Epub 2013 Jul 11.
The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F, BMYB and forkhead box protein M1. DREAM mediates gene repression during the G0 phase and coordinates periodic gene expression with peaks during the G1/S and G2/M phases. Perturbations in DREAM complex regulation shift the balance from quiescence towards proliferation and contribute to the increased mitotic gene expression levels that are frequently observed in cancers with a poor prognosis.
二聚体伙伴、RB 样、E2F 和多皱皮蝇 B 类(DREAM)复合物通过直接连接 p130、p107、E2F、BMYB 和叉头框蛋白 M1,为细胞周期提供了一个以前未被怀疑的统一作用。DREAM 在 G0 期介导基因抑制,并与 G1/S 和 G2/M 期的峰值协调周期性基因表达。DREAM 复合物调节的扰动将平衡从静止状态转向增殖,并导致预后不良的癌症中经常观察到的有丝分裂基因表达水平增加。