采用有机催化不对称 Robinson 环加成反应合成八角倍半萜的四环核心。
Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation.
机构信息
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.
出版信息
Beilstein J Org Chem. 2013 Jun 12;9:1135-40. doi: 10.3762/bjoc.9.126. Print 2013.
Abstract
An enantioselective synthesis of the core framework of neurotrophic Illicium majucin-type sesquiterpenes is described here. This strategy is based on an organocatalyzed asymmetric Robinson annulation and provides an efficient approach for a diversity-oriented synthesis of Illicium natural products that holds remarkable therapeutic potential for neurodegenerative diseases.
摘要
本文描述了一种手性选择性合成具有神经营养作用的八角枫型倍半萜核心骨架的方法。该策略基于有机催化不对称 Robinson 环化反应，为多样性导向合成具有神经退行性疾病显著治疗潜力的天然八角枫产物提供了一种有效方法。
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