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[评估艾滋病毒/艾滋病患者的心血管危险因素——对耶路撒冷哈达萨艾因凯雷姆哈达萨艾滋病中心接受治疗的患者的调查]

[Assessing cardiovascular risk factors among patients living with HIV/AIDS - survey of patients treated at the Hadassah Aids Center, Hadassah Ein Kerem, Jerusalem].

作者信息

Rotshild Victoria, Olshtain-Pops Karen, Maayan Shlomo

机构信息

The Hadassah AIDS Center, Jerusalem, Israel.

出版信息

Harefuah. 2013 Apr;152(4):211-5, 247.

PMID:23844522
Abstract

BACKGROUND

It has recently become evident that people living with HIV/AIDS have an increased cardiovascular risk. The reasons leading to this risk are multifactorial. In this study, we aimed to evaluate the cardiovascular risk (CVR) among patients treated at the Hadassah AIDS Center.

MATERIALS AND METHODS

We conducted a cross-sectional study. CVR was calculated using the Framingham risk score (FRS). LDL-cholesterol optimal levels were defined using National Cholesterol Education Program (NCEP) criteria.

RESULTS

We analyzed data from 150 patients during 2010. Their median age was 41 years and 60% were male. Nearly 52% of our patients were immigrants from Ethiopia. Most patients (90%) were on antiretroviral therapy (ART). The median time for ART exposure was 6.5 years. Rates of hypertension (HTN) (18.5%), diabetes (5.7%) and smoking (25%) were similar to the rates found in the general Israeli population (15%, 5.7% and 24%, respectively). Smoking was significantly less frequent among patients originating from Ethiopia (8%). Increased CVR (FRS >10%) was observed in 21% of the patients. Significantly lower rates were observed among Ethiopian patients (11%), compared with non-Ethiopians (39%). Increased CVR was correlated with increased age (p<0.05), male gender (p=0.034) and HTN (p=0.002), but not with smoking (p=0.53), change in CD4 (p=0.7) or viral suppression (p=0.64).

CONCLUSION

Rates of hypertension, diabetes and smoking among patients living with HIV/AIDS were comparable to those found in the general Israeli population. Significantly lower rates of increased Framingham risk score (>or=10%) were observed among Ethiopian HIV/AIDS patients, than among non-Ethiopians. .

摘要

背景

最近已明显看出,感染艾滋病毒/艾滋病的人患心血管疾病的风险增加。导致这种风险的原因是多方面的。在本研究中,我们旨在评估哈达萨艾滋病中心接受治疗的患者的心血管疾病风险(CVR)。

材料与方法

我们进行了一项横断面研究。使用弗雷明汉风险评分(FRS)计算CVR。根据国家胆固醇教育计划(NCEP)标准定义低密度脂蛋白胆固醇的最佳水平。

结果

我们分析了2010年期间150名患者的数据。他们的中位年龄为41岁,60%为男性。近52%的患者是来自埃塞俄比亚的移民。大多数患者(90%)接受抗逆转录病毒治疗(ART)。ART暴露的中位时间为6.5年。高血压(HTN)(18.5%)、糖尿病(5.7%)和吸烟(25%)的发生率与以色列普通人群中的发生率相似(分别为15%、5.7%和24%)。来自埃塞俄比亚的患者吸烟频率明显较低(8%)。21%的患者观察到CVR增加(FRS>10%)。与非埃塞俄比亚患者(39%)相比,埃塞俄比亚患者中的发生率明显较低(11%)。CVR增加与年龄增加(p<0.05)、男性(p=0.034)和HTN(p=0.002)相关,但与吸烟(p=0.53)、CD4变化(p=0.7)或病毒抑制(p=0.64)无关。

结论

艾滋病毒/艾滋病患者中的高血压、糖尿病和吸烟发生率与以色列普通人群中的发生率相当。埃塞俄比亚艾滋病毒/艾滋病患者中弗雷明汉风险评分增加(≥10%)的发生率明显低于非埃塞俄比亚患者。

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