Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
J Perinatol. 2013 Nov;33(11):882-6. doi: 10.1038/jp.2013.77. Epub 2013 Jul 11.
To investigate the association between early hyperglycemia and growth and development from hospital discharge to 2 years corrected age (CA) in very low birth weight (VLBW) infants.
Blood glucose levels during the first 14 days after birth, weight, length and occipital-frontal circumference (OFC) at birth, hospital discharge and 4, 12 and 24 months CA, Bayley developmental scores at 12 and 24 months CA, and information on multiple clinical variables were recorded on VLBW preterm infants (N=80). The relationships between hyperglycemia, growth and developmental scores were determined using linear mixed effects regression.
Hyperglycemia was a strong predictor of poor rate of increase in weight, length and OFC until 24 months CA. Hyperglycemia was not associated with lower scores on the Bayley scales.
Neonatal hyperglycemia was associated with poor physical growth until at least 2 years CA in this cohort of VLBW preterm infants.
研究极低出生体重儿（VLBW）从出生出院至 2 年校正年龄（CA）期间早期高血糖与生长发育的关系。
记录 80 例 VLBW 早产儿出生时、出生后第 14 天、出院时及 4、12 和 24 个月 CA 的血糖水平、体重、身长和头围（OFC），以及贝利发育评分（Bayley scales），同时记录多个临床变量的信息。采用线性混合效应回归分析高血糖与生长发育评分之间的关系。
高血糖是影响体重、身长和 OFC 至 24 个月 CA 期间增长率的重要因素。高血糖与贝利评分较低无关。
在本队列的 VLBW 早产儿中，新生儿高血糖与至少 2 年 CA 时的体格生长不良有关。
