胰腺癌干细胞：它们在胰腺癌患者预后中的作用及未来走向？

Pancreatic cancer stem cells: their role in pancreatic cancer patient outcomes and what is future?

作者信息

Habib Muzzamal, Saif Muhammad Wasif

机构信息

Steward St. Elizabeth Medical Center, Tufts University School of Medicine. Boston, MA 02111, USA.

出版信息

JOP. 2013 Jul 10;14(4):401-4. doi: 10.6092/1590-8577/1658.

DOI:10.6092/1590-8577/1658

PMID:23846937

Abstract

There is emerging evidence that stem cells might be playing an important role when it comes to cancer aggressiveness, metastasis, recurrence, resistance to chemotherapy and overall survival in hematologic malignancies as well as solid tumors including pancreatic adenocarcinoma. We review Abstract #e15058 presented at the 2013 ASCO Annual Meeting in Chicago by Andrikou et al.. Pancreatic cancer patients over-expressing pancreatic cancer stem cell markers were associated with aggressive tumors and worse survival.

摘要

越来越多的证据表明，在血液系统恶性肿瘤以及包括胰腺腺癌在内的实体瘤中，干细胞在癌症侵袭性、转移、复发、化疗耐药性和总体生存率方面可能发挥着重要作用。我们回顾了Andrikou等人在2013年芝加哥美国临床肿瘤学会年会上发表的摘要#e15058。过度表达胰腺癌干细胞标志物的胰腺癌患者与侵袭性肿瘤和较差的生存率相关。