School of Life Sciences, Kingston University , Kingston upon Thames , UK.
Front Endocrinol (Lausanne). 2013 Jul 8;4:80. doi: 10.3389/fendo.2013.00080. eCollection 2013.
(i) a range of pathologies such as prostate cancer, (ii) medication contra-indications, (iii) disruption to the endocrine system, and (iv) potential confounding effects on doping tests. Conjugation of anabolic steroids during phase II metabolism, mainly driven by UDP-glucuronosyltransferase (UGT) 2B7, 2B15, and 2B17, has been shown to be impaired in vitro by a range of compounds including xenobiotics and pharmaceuticals. Following early reports on the effects of a range of xenobiotics on UGT activity in vitro, the work was extended to reveal similar effects with common non-steroidal anti-inflammatory drugs. Notably, recent studies have evidenced inhibitory effects of the common foodstuffs green tea and red wine, along with their constituent flavonoids and catechins. This review amalgamates the existing evidence for the inhibitory effects of various pharmaceutical and dietary substances on the rate of UGT glucuronidation of testosterone; and evaluates the potential consequences for health linked to steroid levels, interaction with treatment drugs metabolized by the UGT enzyme and steroid abuse in sport.
摄入的物质可能会干扰睾酮代谢，其影响包括：(i) 一系列病理学，如前列腺癌；(ii) 药物禁忌；(iii) 内分泌系统紊乱；以及 (iv) 对兴奋剂检测的潜在干扰。在 II 期代谢过程中，同化类固醇的结合主要由 UDP-葡糖醛酸基转移酶（UGT）2B7、2B15 和 2B17 驱动，体外研究表明，多种化合物，包括外源性物质和药物，会损害其结合能力。在早期报告了一系列外源性物质对 UGT 活性的体外影响之后，研究工作扩展到揭示常见非甾体抗炎药也具有类似的影响。值得注意的是，最近的研究表明，常见的食物绿茶和红酒及其组成的类黄酮和儿茶素有抑制作用。本文综述了各种药物和饮食物质对睾酮 UGT 葡糖醛酸化速率的抑制作用的现有证据；并评估了与类固醇水平相关的健康风险、与 UGT 酶代谢的治疗药物的相互作用以及运动中的类固醇滥用。
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