Key Laboratory of Tumor Molecular Biology in Binzhou Medical University, Department of Biochemistry and Molecular Biology, Binzhou Medical University, YanTai, ShanDong 264003, PR China.
FEBS Lett. 2013 Aug 19;587(16):2675-81. doi: 10.1016/j.febslet.2013.07.004. Epub 2013 Jul 11.
MicroRNAs have tumor suppressive or oncogenic roles in carcinogenesis. This study aimed to investigate the mechanism of let-7c in suppressing lung cancer cell proliferation. First, let-7c was revealed to be able to inhibit lung adenocarcinoma cell proliferation significantly. TRIB2 was further demonstrated to be a novel target and negatively regulated by let-7c. As downstream signals of TRIB2, the activities of C/EBP-α and phosphorylated p38MAPK were increased obviously in let-7c-treated cells compared with controls. Our results demonstrate that, through regulating the expression of TRIB2 and its downstream factors, let-7c can effectively inhibit A549 cell proliferation in vitro and in vivo.
MicroRNAs 在肿瘤发生中具有肿瘤抑制或致癌作用。本研究旨在探讨 let-7c 抑制肺癌细胞增殖的机制。首先，发现 let-7c 能够显著抑制肺腺癌细胞增殖。进一步证实 TRIB2 是 let-7c 的一个新的靶基因，并受其负调控。作为 TRIB2 的下游信号，与对照组相比，let-7c 处理的细胞中 C/EBP-α 和磷酸化 p38MAPK 的活性明显增加。我们的结果表明，通过调节 TRIB2 及其下游因子的表达，let-7c 可以有效地抑制 A549 细胞在体外和体内的增殖。
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