Department of Neurology, Corlu State Hospital, Tekirdag, Turkey.
Eur Rev Med Pharmacol Sci. 2013 Jul;17(13):1778-81.
Nerve blockades are used for the treatment of acute migraine episodes in emergency room conditions and beneficial results are obtained from this clinical use. Although this is the case, there are limited numbers of studies investigating the long-term effects of such an approach.
In this investigation, we had 26 patients diagnosed as migraine based on the ICHD II criteria, these were injected with 1% lidocaine at supraorbital and infraorbital nerve localizations and clinical results were evaluated after 6 months of follow-up. All patients received 1.5 ml of 1% lidocaine bilaterally for supraorbital and infraorbital nerves with three day intervals for three times. Clinical evaluation was conducted by recording the number of migraine episodes per month together with migraine disability assessment scale (MIDAS) and visual analog scale (VAS) scores before and six months after the treatment.
Mean age of the patients recruited in the study was 31.1±10.2 years. Disease duration was 8.1±5.4 years, the duration of the headache was 28.4±18.4 hours, mean number of episodes before treatment was 9.9±5.2, mean MIDAS was calculated as 3.2±0.8, and VAS as 9.0±1.0. Six months after the treatment, mean number of attacks was 2.0±3.0, MIDAS was 1.4±0.9 and VAS was 3.5±3.6. There was a statistically significant difference between the results obtained before and after the treatment.
Injecting 1% of lidocaine to supraorbital and infraorbital nerve for three times prevents the acute migraine episodes effectively during the 6-months of follow-up without having any significant side effects.
神经阻滞用于治疗急诊室条件下的急性偏头痛发作,这种临床应用取得了有益的效果。尽管如此,关于这种方法的长期效果的研究数量有限。
在这项研究中,我们有 26 名患者根据 ICHD II 标准诊断为偏头痛,这些患者在眶上和眶下神经定位处注射 1%利多卡因,并在 6 个月的随访后评估临床结果。所有患者双侧眶上和眶下神经各接受 1.5 毫升 1%利多卡因,间隔 3 天,共 3 次。临床评估通过记录每月偏头痛发作次数、偏头痛残疾评估量表(MIDAS)和视觉模拟量表(VAS)评分来进行,在治疗前和治疗后 6 个月进行。
研究中纳入的患者平均年龄为 31.1±10.2 岁。疾病持续时间为 8.1±5.4 年,头痛持续时间为 28.4±18.4 小时,治疗前平均发作次数为 9.9±5.2,平均 MIDAS 为 3.2±0.8,VAS 为 9.0±1.0。治疗 6 个月后,平均发作次数为 2.0±3.0,MIDAS 为 1.4±0.9,VAS 为 3.5±3.6。治疗前后结果有统计学显著差异。
眶上和眶下神经注射 1%利多卡因 3 次可有效预防急性偏头痛发作,在 6 个月的随访期间无明显副作用。