在温和无过渡金属条件下，将甲基亚胺直接转化为α-亚氨基腈。
Direct transformation of methyl imines to α-iminonitriles under mild and transition-metal-free conditions.
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, PR China.
出版信息
Chemistry. 2013 Aug 19;19(34):11199-202. doi: 10.1002/chem.201301933. Epub 2013 Jul 12.
PMID:23853059
Abstract
A novel transformation of methyl imines into α-iminonitriles under mild and transition-metal-free conditions is described. Three C sp 3-H bonds are cleaved in a radical pathway at room temperature under air. Simple bromide salts are employed to assist this radical process (see scheme; FG=functional group, PIDA = iodobenzene diacetate, TMS = trimethylsilyl).
摘要
描述了一种在温和条件下且无需过渡金属的情况下将甲基亚胺转化为α-亚氨基腈的新方法。在室温下空气存在的条件下，通过自由基途径断裂了三个 Csp3-H 键。简单的溴化物盐被用来辅助这个自由基过程（见方案；FG=官能团，PIDA=碘苯二乙酸酯，TMS=三甲基硅基）。
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