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降钙素原作为脑室-腹腔分流感染的早期诊断标志物。

Procalcitonin as an early diagnostic marker for ventriculoperitoneal shunt infections.

机构信息

1 Department of Neurosurgery, Saitama Municipal Hospital , Saitama, Japan .

出版信息

Surg Infect (Larchmt). 2013 Oct;14(5):433-6. doi: 10.1089/sur.2012.087. Epub 2013 Jul 17.

Abstract

BACKGROUND

Procalcitonin (PCT) has been considered a more reliable marker than others because of its specificity for bacterial infection.

METHODS

Case report and review of the literature.

RESULTS

A 50-year-old male was diagnosed with subarachnoid hemorrhage, intraventricular hemorrhage, and intracerebral hemorrhage. We performed a ruptured aneurysm clipping and left unilateral external ventricular drainage. We also performed ventriculoperitoneal (VP) shunt placement in the course; however, VP shunt infection was indicated by fever, increased C-reactive protein concentration and leukocytosis. The cerebrospinal fluid culture showed methicillin-resistant Staphylococcus epidermidis but the serum PCT concentration was quite low.

CONCLUSIONS

Although PCT is considered a more reliable serological marker of bacterial meningitis in several reports, the serum PCT concentration did not reflect the bacterial VP shunt infection that was present in our case.

摘要

背景

降钙素原 (PCT) 因其对细菌感染的特异性而被认为是比其他标志物更可靠的标志物。

方法

病例报告和文献复习。

结果

一名 50 岁男性被诊断为蛛网膜下腔出血、脑室内出血和脑出血。我们进行了破裂的动脉瘤夹闭和左侧单侧脑室外引流。在这个过程中,我们还进行了脑室-腹腔(VP)分流术;然而,发热、C 反应蛋白浓度升高和白细胞增多提示 VP 分流感染。脑脊液培养显示耐甲氧西林表皮葡萄球菌,但血清 PCT 浓度相当低。

结论

尽管 PCT 在几项报告中被认为是细菌性脑膜炎更可靠的血清学标志物,但在我们的病例中,血清 PCT 浓度并未反映出存在细菌 VP 分流感染。

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