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TGF-β1 多态性对系统性硬化症的影响:系统评价和现有文献的荟萃分析。

The effect of TGF-β1 polymorphism on systemic sclerosis: a systematic review and pooled analysis of available literature.

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.

出版信息

Rheumatol Int. 2013 Nov;33(11):2859-65. doi: 10.1007/s00296-013-2826-9. Epub 2013 Jul 18.

Abstract

Transforming growth factor-β1 (TGF-β1) plays an important role in the pathogenesis of systemic sclerosis (SSc). To investigate whether TGF-β1 gene promoter polymorphisms were associated with the susceptibility of SSc, we performed a meta-analysis based on all available studies through PubMed, Elsevier Science Direct, Embase, and Chinese Biomedical, China National Knowledge Infrastructure and Google Scholar with the last report up to March 15, 2013. Crude odds ratios with 95% confidence intervals were used to estimate the strength of the association. A fixed or random effects model was adopted according to heterogeneity test. Heterogeneity among studies was evaluated using I (2) . Meta-regression was used to explore potential sources of between-study heterogeneity. Publication bias was estimated using Begg's and Egger's test. Totally, seven papers with 663 SSc patients and 908 healthy controls were subjected to the final analysis. These studies encompass seven for TGF-β1 codon 10, three for codon 25 and three for -509C/T. We failed to detect any association of these promoter polymorphism with SSc susceptibility. For TGF-β1 codon 10 polymorphism, subgroup analyses by race, genotype testing method and classification of SSc were further performed. Similarly, no association was observed. Significant heterogeneity was detected among the studies in all genetic models of TGF-β1 codon 10 polymorphism. Publication bias was absent. Taken together, our meta-analysis did not provided an evidence of confirming association between TGF-β1 (codon 10, codon 25, -509C/T) gene polymorphism and SSc. Nevertheless, due to smaller sample sizes, larger sample studies including different ethnic groups should be considered in future to confirm our results.

摘要

转化生长因子-β1(TGF-β1)在系统性硬化症(SSc)的发病机制中起重要作用。为了研究 TGF-β1 基因启动子多态性是否与 SSc 的易感性相关,我们通过 PubMed、Elsevier Science Direct、Embase 和中国生物医学文献数据库、中国国家知识基础设施和 Google Scholar 进行了一项荟萃分析,这些数据库的最后检索日期截至 2013 年 3 月 15 日。使用粗比值比及其 95%置信区间来评估关联的强度。根据异质性检验,采用固定或随机效应模型。使用 I(2)来评估研究间的异质性。采用 Meta 回归来探索研究间异质性的潜在来源。采用 Begg 和 Egger 检验来评估发表偏倚。最终有 7 篇文献(共 663 例 SSc 患者和 908 例健康对照者)纳入最终分析。这些研究包括 TGF-β1 密码子 10 的 7 项研究、密码子 25 的 3 项研究和-509C/T 的 3 项研究。我们未能发现这些启动子多态性与 SSc 易感性之间存在任何关联。对于 TGF-β1 密码子 10 多态性,我们进一步根据种族、基因型检测方法和 SSc 分类进行了亚组分析。同样,未观察到关联。在所有 TGF-β1 密码子 10 多态性的遗传模型中,研究间均存在显著的异质性。未发现发表偏倚。总之,我们的荟萃分析没有提供证据证实 TGF-β1(密码子 10、密码子 25、-509C/T)基因多态性与 SSc 之间存在关联。然而,由于样本量较小,未来应考虑包括不同种族的更大样本研究来验证我们的结果。

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