Zivkovic R V, Kostic M M, Siems W, Werner A, Mojsilovic L P, Gerber G
Institute of Biochemistry, Faculty of Medicine, University Belgrade, Yugoslavia.
Biomed Biochim Acta. 1990;49(2-3):S172-7.
The effects of 1, 5 and 20 mmol/l phenylhydrazine hydrochloride on energy metabolism of rabbit erythrocyte and reticulocyte were studied. Significant depression of glycolysis, accompanied by loss of adenine nucleotides, mainly due to an extensive decline of ATP, was found in erythrocytes. Energy metabolism of reticulocytes appears to be more sensitive to deleterious effects of this drug. The declines of ATP and sum of all adenine nucleotides, as well as the accumulation of hypoxanthine were twofold in reticulocyte-rich red cell suspensions compared with suspensions of mature erythrocytes. It can be concluded that these changes are the consequence of lower energy production due to phenylhydrazine hydrochloride-induced inhibition of oxidative phosphorylation.
研究了1、5和20毫摩尔/升盐酸苯肼对兔红细胞和网织红细胞能量代谢的影响。在红细胞中发现糖酵解显著抑制，伴随着腺嘌呤核苷酸的丢失，主要是由于ATP大量减少。网织红细胞的能量代谢似乎对这种药物的有害作用更敏感。与成熟红细胞悬液相比，富含网织红细胞的红细胞悬液中ATP和所有腺嘌呤核苷酸总和的下降以及次黄嘌呤的积累增加了两倍。可以得出结论，这些变化是盐酸苯肼诱导的氧化磷酸化抑制导致能量产生降低的结果。
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