超越 HLA：器官移植中 nHLA 抗体的研究综述。
Moving beyond HLA: a review of nHLA antibodies in organ transplantation.
机构信息
California Pacific Medical Center, Research Institute, San Francisco, CA, USA.
出版信息
Hum Immunol. 2013 Nov;74(11):1486-90. doi: 10.1016/j.humimm.2013.07.001. Epub 2013 Jul 19.
Abstract
Given the finite graft life expectancy of HLA identical organ transplants and the recognition of humoral graft injury in the absence of donor directed anti-HLA antibodies, the clinical impact of antibodies against non-HLA (nHLA) antigens in transplant injury is being increasingly recognized. The recognition of the impact of nHLA antigen discrepancies between donor and recipient on transplant outcomes is timely given the advances in rapid and lower cost sequencing methods that can soon provide complete maps of all recipient and donor HLA and nHLA mismatch data. In this review, we present a summary of recent reports evaluating the role of nHLA antibodies and their relevance to the field of organ transplantation.
摘要
鉴于 HLA 相同器官移植的有限移植物预期寿命，以及在没有供体定向抗 HLA 抗体的情况下识别体液性移植物损伤，非 HLA（nHLA）抗原抗体在移植损伤中的临床影响正日益受到重视。鉴于快速和低成本测序方法的进步，这些方法很快就能提供所有受者和供者 HLA 和 nHLA 错配数据的完整图谱，因此，认识到供者和受者之间 nHLA 抗原差异对移植结果的影响是及时的。在这篇综述中，我们总结了最近评估 nHLA 抗体作用及其与器官移植领域相关性的报告。
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