恐惧条件反射回路中的突触可塑性：通过刺激内侧膝状体在杏仁核外侧核诱导长时程增强。
Synaptic plasticity in fear conditioning circuits: induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body.
作者信息
Clugnet M C, LeDoux J E
机构信息
Center for Neural Science, New York University, New York 10003.
出版信息
J Neurosci. 1990 Aug;10(8):2818-24. doi: 10.1523/JNEUROSCI.10-08-02818.1990.
Abstract
Electrical stimulation of the medial geniculate body in the anesthetized rat produces an evoked potential in the lateral nucleus of the amygdala. The potential varies in amplitude with stimulus intensity and reaches peak amplitude in 8.5 msec on the average. High-frequency stimulation of the pathway produces long-lasting increases in the amplitude and slope of the potential. These robust and enduring experience-dependent modifications in neural transmission occur in a pathway known to be involved in the formation of emotional memories and may offer a means for examining the cellular mechanisms of emotional learning, as well as a new approach to questions concerning the relevance of long-term potentiation to normal mnemonic processes.
摘要
对麻醉大鼠的内侧膝状体进行电刺激，会在杏仁核外侧核产生诱发电位。该电位的振幅随刺激强度而变化，平均在8.5毫秒时达到峰值振幅。对该通路进行高频刺激会使电位的振幅和斜率产生持久增加。这些在神经传递中强大且持久的依赖经验的改变发生在一条已知参与情绪记忆形成的通路中，可能为研究情绪学习的细胞机制提供一种方法，以及为有关长时程增强与正常记忆过程相关性的问题提供一种新方法。
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