细胞外基质在肌腱和韧带中的功能特化。
Specialisation of extracellular matrix for function in tendons and ligaments.
作者信息
Birch Helen L, Thorpe Chavaunne T, Rumian Adam P
机构信息
Institute of Orthopaedics and Musculoskeletal Science, University College London, RNOH, Brockley Hill, Stanmore, U.K.
出版信息
Muscles Ligaments Tendons J. 2013 May 21;3(1):12-22. doi: 10.11138/mltj/2013.3.1.012. Print 2013 Jan.
Tendons and ligaments are similar structures in terms of their composition, organisation and mechanical properties. The distinction between them stems from their anatomical location; tendons form a link between muscle and bone while ligaments link bones to bones. A range of overlapping functions can be assigned to tendon and ligaments and each structure has specific mechanical properties which appear to be suited for particular in vivo function. The extracellular matrix in tendon and ligament varies in accordance with function, providing appropriate mechanical properties. The most useful framework in which to consider extracellular matrix differences therefore is that of function rather than anatomical location. In this review we discuss what is known about the relationship between functional requirements, structural properties from molecular to gross level, cellular gene expression and matrix turnover. The relevance of this information is considered by reviewing clinical aspects of tendon and ligament repair and reconstructive procedures.
就其组成、组织结构和力学性能而言，肌腱和韧带是相似的结构。它们之间的区别源于其解剖位置；肌腱在肌肉和骨骼之间形成连接，而韧带则将骨与骨相连。肌腱和韧带具有一系列重叠的功能，并且每个结构都具有特定的力学性能，这些性能似乎适合特定的体内功能。肌腱和韧带中的细胞外基质根据功能而有所不同，从而提供适当的力学性能。因此，考虑细胞外基质差异的最有用框架是功能框架，而非解剖位置框架。在本综述中，我们讨论了关于功能需求、从分子水平到宏观水平的结构特性、细胞基因表达和基质更新之间关系的已知信息。通过回顾肌腱和韧带修复及重建手术的临床方面来考量这些信息的相关性。
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