Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota.
Clin J Am Soc Nephrol. 2013 Nov;8(11):1979-87. doi: 10.2215/CJN.03400313. Epub 2013 Jul 25.
A young male is evaluated for nephrotic-range proteinuria, hypercalciuria, and an elevated serum creatinine. A renal biopsy is performed and shows focal global glomerulosclerosis. The absence of nephrotic syndrome suggest that glomerulosclerosis was a secondary process. Further analysis of the proteinuria showed it to be due mainly to low-molecular weight proteins. The case illustrates the crucial role of electron microscopy as well as evaluation of the identity of the proteinuria that accompanies a biopsy finding of focal and global or focal and segmental glomerulosclerosis.
一位年轻男性因肾病范围蛋白尿、高钙尿和血清肌酐升高而就诊。进行了肾活检,结果显示局灶性全球肾小球硬化。肾病综合征的缺失提示肾小球硬化是一个继发过程。对蛋白尿的进一步分析表明,它主要是由于低分子量蛋白质。该病例说明了电子显微镜检查以及伴随局灶性和全球性或局灶性和节段性肾小球硬化活检发现的蛋白尿的特征评估的重要作用。