Wohlrab W, Taube K M, Kuchenbecker I
Klinik und Poliklinik für Hautkrankheiten, Martin-Luther-Universität Halle-Wittenberg.
Z Hautkr. 1990 Jun;65(6):534-7.
Several attempts have been made to optimize the efficiency of topical glucocorticoids (GC) and, at the same time, to minimize their side effects. In this respect, we should first consider attenuated GC. Dependent on the urea concentration, hydrocortisone (HC) in combination with urea results in both a considerable increase of the HC liberation from the ointment base, as well as an increased penetration rate of HC into the individual skin layers. If we apply these mechanisms to a preparation containing low HC concentrations, a given therapeutic effect can be obtained with definitely reduced HC concentrations. On the other hand, the therapeutic efficiency or the penetration rate of GC can not be deduced from the galenic formulation, the drug concentration, or the amount of urea.
人们已经进行了多次尝试来优化局部糖皮质激素（GC）的疗效，同时尽量减少其副作用。在这方面，我们首先应考虑减效型GC。氢化可的松（HC）与尿素结合，根据尿素浓度的不同，既能使HC从软膏基质中的释放量显著增加，又能提高HC进入各皮肤层的渗透率。如果将这些机制应用于HC浓度较低的制剂中，那么在HC浓度明显降低的情况下仍可获得一定的治疗效果。另一方面，无法从药剂剂型、药物浓度或尿素含量推断出GC的治疗效果或渗透率。
