[与胰岛素抵抗和葡萄糖不耐受相关的高脂饮食诱导肥胖模型]
[Model of high-fat diet-induced obesity associated to insulin resistance and glucose intolerance].
作者信息
White Pollyanna A S, Cercato Luana M, Araújo Jéssica M D, Souza Lucas A, Soares Andréa F, Barbosa Ana Paula O, Neto José M de R, Marçal Anderson C, Machado Ubiratan F, Camargo Enilton A, Santos Márcio R V, Brito Luciana C
机构信息
Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.
出版信息
Arq Bras Endocrinol Metabol. 2013 Jul;57(5):339-45. doi: 10.1590/s0004-27302013000500002.
OBJECTIVE
Validate a model of high-fat diet-induced obesity, of low cost, easy reproducibility, that could express characteristics observed in human, and would enable subsequent therapy proposals.
MATERIALS AND METHODS
Sixteen Swiss mice received a standard diet (DP) or high-fat diet (DH) for 10 weeks.
RESULTS
Although the DP group had greater water (p < 0.01) and feed (p < 0.001) consumption, the DH group had greater body weight (p < 0.5) and adipose tissue gain (p < 0.001), favoring higher adiposity index (p < 0.001), glucose (p < 0.01), and area under the curve in the insulin (p < 0.001) and glucose (p < 0.01) tolerance tests.
CONCLUSION
A high-fat diet-induced obesity model has been validated, which was also associated with insulin resistance and glucose intolerance after a period of 10 weeks.
目的
验证一种低成本、易于复制的高脂饮食诱导肥胖模型，该模型能够表现出人类观察到的特征，并有助于后续提出治疗方案。
材料与方法
16只瑞士小鼠接受标准饮食（DP）或高脂饮食（DH）10周。
结果
尽管DP组的水摄入量（p < 0.01）和饲料摄入量（p < 0.001）更高，但DH组的体重（p < 0.5）和脂肪组织增加量（p < 0.001）更大，有利于更高的肥胖指数（p < 0.001）、血糖（p < 0.01）以及胰岛素（p < 0.001）和血糖（p < 0.01）耐量试验中的曲线下面积。
结论
已验证了一种高脂饮食诱导肥胖模型，该模型在10周后还与胰岛素抵抗和葡萄糖不耐受有关。
Zotero 插件