Molecular and Human Genetics Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Kolkata, 700032, WB, India.
Biometals. 2013 Oct;26(5):855-62. doi: 10.1007/s10534-013-9652-0. Epub 2013 Aug 2.
Chronic exposure to arsenic through drinking water affects nearly 26 million individuals in West Bengal, India. Cytogenetic biomarkers like urothelial micronucleus (MN) are extensively used to monitor arsenic exposed population. In 2004-2005, 145 arsenic exposed individuals and 60 unexposed controls were surveyed of which 128 exposed individuals and 54 unexposed controls could be followed up in 2010-2011. In 2004-2005, the extent of arsenic content in the drinking water was 348.23 ± 102.67 μg/L, which was significantly lowered to 5.60 ± 10.83 μg/L in 2010-2011. Comparing the data obtained between 2004-2005 and 2010-2011, there was a significant decline in the MN frequency, when assayed in 2010-2011 compared to 2004-2005. Hence, we infer that urothelial MN can be utilized as a good biomarker in detecting remedial effects from toxicity of the low dose of arsenic through drinking water.
慢性经饮用水暴露砷影响了印度西孟加拉邦近 2600 万人。尿路上皮微核（MN）等细胞遗传学生物标志物被广泛用于监测砷暴露人群。2004-2005 年，调查了 145 名砷暴露个体和 60 名未暴露对照者，其中 128 名暴露个体和 54 名未暴露对照者可在 2010-2011 年进行随访。2004-2005 年，饮用水中砷含量为 348.23±102.67μg/L，2010-2011 年显著降低至 5.60±10.83μg/L。将 2004-2005 年和 2010-2011 年的数据进行比较，2010-2011 年 MN 频率明显低于 2004-2005 年。因此，我们推断尿路上皮 MN 可作为一种良好的生物标志物，用于检测通过饮用水摄入低剂量砷的毒性的治疗效果。
