白细胞介素-33 对原发性干燥综合征患者间质性肺病发展的潜在贡献。
Potential contribution of interleukin-33 to the development of interstitial lung disease in patients with primary Sjogren's Syndrome.
机构信息
Department of Rheumatology, 1st Affiliated Hospital of China Medical University, Shenyang 110001, PR China; Department of Rheumatology, 2nd Affiliated Hospital of Dalian Medical University, Dalian 116021, PR China.
出版信息
Cytokine. 2013 Oct;64(1):22-4. doi: 10.1016/j.cyto.2013.07.006. Epub 2013 Jul 31.
OBJECTIVE
To determine whether interleukin (IL)-33 and soluble ST2 (sST2) are associated with primary Sjogren's Syndrome (pSS).
METHODS
Serum levels of IL-33 and sST2 in 110 pSS patients and 78 healthy controls were measured by enzyme-linked immunosorbent assay (ELISA). Immunoglobulins, rheumatoid factors (RF), antinuclear antibody (ANA), anti-SSA/RO-52 antibody, anti-SSB antibody and erythrocyte sedimentation rate (ESR) were measured by standard laboratory techniques. Interstitial lung disease (ILD) was identified on high-resolution computed tomography (HRCT). Disease activity in pSS was scored with the European League Against Rheumatism Sjogren's Syndrome Disease Activity Index (ESSDAI).
RESULTS
Serum levels of IL-33 and sST2 were significantly elevated in pSS patients, especially in patients with ILD. There was significant positive correlation between IL-33 and RF, anti-SSB antibody.
CONCLUSION
IL-33/sST2 may be involved in the pathogenesis of pSS and partly contribute to the ILD in pSS patients.
目的
探讨白细胞介素（IL）-33 和可溶性 ST2（sST2）与原发性干燥综合征（pSS）的相关性。
方法
采用酶联免疫吸附试验（ELISA）检测 110 例 pSS 患者和 78 名健康对照者血清中 IL-33 和 sST2 的水平。采用标准实验室技术检测免疫球蛋白、类风湿因子（RF）、抗核抗体（ANA）、抗 SSA/RO-52 抗体、抗 SSB 抗体和红细胞沉降率（ESR）。采用高分辨率计算机断层扫描（HRCT）诊断间质性肺疾病（ILD）。采用欧洲抗风湿病联盟干燥综合征疾病活动指数（ESSDAI）对 pSS 患者的疾病活动进行评分。
结果
pSS 患者血清中 IL-33 和 sST2 水平显著升高，尤其是在伴有ILD 的患者中。IL-33 与 RF、抗 SSB 抗体呈显著正相关。
结论
IL-33/sST2 可能参与 pSS 的发病机制，并部分导致 pSS 患者发生 ILD。
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