INIMEC-CONICET.
Psicothema. 2013;25(3):355-62. doi: 10.7334/psicothema2012.95.
Prenatal exposure to ethanol and later socially mediated exposure predicts ethanol intake in human adolescents. Animal rat models indicate that brief interactions with an ethanol-intoxicated peer result in heightened preference for ethanol odor and ethanol intake.
This study assessed preference for ethanol odor in adolescent male rats (observers) following social interaction with an ethanol intoxicated peer (demonstrators) as a function of prenatal ethanol exposure (gestational days 17-20, 1.0 g/kg, intragastric). Social behavior and locomotion during social interaction was also measured.
Social investigation was greater in observers that interacted with an intoxicated demonstrator in comparison to those that interacted with a sober peer. Social contact increased when the demonstrator was under the effects of ethanol, but only if the observer had experienced ethanol prenatally. Ethanol inhibited locomotion in the demonstrators. Finally, social interaction with an intoxicated peer during adolescence as well as prenatal ethanol experience increased preference for ethanol odor.
Fetal exposure to ethanol mediated by maternal intoxication at late gestation or by interaction with an intoxicated peer at adolescence heightens preference for the chemosensory cues of the drug.
产前暴露于乙醇以及随后的社会介导暴露可预测人类青少年对乙醇的摄入。动物大鼠模型表明，与醉酒同伴进行短暂互动会导致对乙醇气味和乙醇摄入的偏好增加。
本研究评估了青春期雄性大鼠（观察者）在与醉酒同伴（示范者）进行社交互动后对乙醇气味的偏好，作为产前乙醇暴露（妊娠第 17-20 天，1.0 g/kg，灌胃）的函数。社交互动期间还测量了社交行为和运动。
与与清醒同伴互动的观察者相比，与醉酒示范者互动的观察者的社交调查更多。当示范者处于醉酒状态时，社交接触增加，但前提是观察者在产前经历过乙醇。乙醇抑制了示范者的运动。最后，青春期与醉酒同伴的社交互动以及产前乙醇暴露增加了对乙醇气味的偏好。
妊娠晚期母体醉酒或青春期与醉酒同伴互动引起的胎儿乙醇暴露会增加对药物化学感觉线索的偏好。
