N-acetyl-β-hexosaminidase in chronic tonsillitis and tonsillar hypertrophy.
作者信息
Zagor Mariola, Minarowska Alina, Knaś Małgorzata, Krajewska Katarzyna, Niemcunowicz-Janica Anna, Marciniak Justyna, Bierć Marcin, Zaniewska Agnieszka, Minarowski Lukasz, Jackowska Anna, Jackowski Tomasz, Zwierz Krzysztof, Szajda Sławomir
机构信息
Department of Otolaryngology, Stomatology Division, I Faculty of the Warsaw Medical University, Warsaw, Poland.
出版信息
Otolaryngol Pol. 2013 Jul-Aug;67(4):204-8. doi: 10.1016/j.otpol.2013.05.003. Epub 2013 May 24.
BACKGROUND
The concentration and specific activity of N-acetyl-β-hexosaminidase (HEX) in palatine tonsils with chronic tonsillitis and tonsillar hypertrophy give insight in tonsillar tissue remodeling and constitute a potential marker for diagnosis and treatment of chronic tonsillitis and tonsillar hypertrophy.
AIM
Determining the concentration and specific activity of N-acetyl-β-hexosaminidase in palatine tonsils with hypertrophy and chronic tonsillitis.
METHODS
HEX activity was analyzed by the method of Marciniak et al. with p-nitrophenyl N-acetyl-β-glucosaminepyranoside as a substrate.
RESULTS
The concentration and specific activity of HEX in palatine tonsils in patients with tonsillar hypertrophy and chronic tonsillitis both in childhood and adulthood significantly increase in comparison to healthy individuals.
CONCLUSIONS
Our data demonstrate the presence of HEX in palatine tonsils and indicate on significant increase of its concentration and specific activity. Based on content and specific HEX activity we suggest that tonsils with hypertrophy and chronic tonsillitis should be treated as identical unit irrespectively of age.
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