p53 蛋白和 MMP-2 肿瘤/基质细胞表达在卵巢肿瘤进展性生长中的作用。
The role of p53 protein and MMP-2 tumor/stromal cells expression on progressive growth of ovarian neoplasms.
机构信息
Department of Pathomorphology and Oncological Cytology, Wrocław Medical University, Wrocław, Poland.
出版信息
Cancer Invest. 2013 Aug;31(7):472-9. doi: 10.3109/07357907.2013.820320.
The aim of our study was to evaluate p53 gene/protein status and MMP-2 expression in respect to ovarian tumors progress to define the role of these markers in the metastasis of ovarian carcinomas. MMP-2 and p53 alterations were evaluated on 80 malignant, 30 benign ovarian tumors, and 62 metastatic lesions by using HRM method for mutations in p53 gene and by using RT-PCR for mRNA MMP-2 level. Our data indicate that parallel expression of MMP-2 epithelial/stromal cells and p53 may enhance cells invasion and metastasis in ovarian carcinoma.
我们的研究目的是评估 p53 基因/蛋白状态和 MMP-2 表达在卵巢肿瘤进展方面的情况，以确定这些标志物在卵巢癌转移中的作用。使用 HRM 方法检测 p53 基因突变，使用 RT-PCR 检测 MMP-2 mRNA 水平，评估 80 例恶性、30 例良性卵巢肿瘤和 62 例转移病变中 MMP-2 和 p53 的改变。我们的数据表明，MMP-2 上皮/间质细胞和 p53 的平行表达可能增强卵巢癌的细胞侵袭和转移。
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