Department of Behavioural Neurobiology, Max Planck Institute for Ornithology, 82319, Seewiesen, Germany; Department of Developmental and Behavioral Neurobiology, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands.
Eur J Neurosci. 2013 Nov;38(9):3338-44. doi: 10.1111/ejn.12329. Epub 2013 Aug 11.
During song learning, vocal patterns are matched to an auditory memory acquired from a tutor, a process involving sensorimotor feedback. Song sensorimotor learning and song production of birds is controlled by a set of interconnected brain nuclei, the song control system. In male zebra finches, the beginning of the sensorimotor phase of song learning parallels an increase of the brain-derived neurotrophic factor (BDNF) in just one part of the song control system, the forebrain nucleus HVC. We report here that transient BDNF-mRNA upregulation in the HVC results in a maximized copying of song syllables. Each treated bird shows motor learning to an extent similar to that of the selected best learners among untreated zebra finches. Because this result was not found following BDNF overexpression in the target areas of HVC within the song system, HVC-anchored mechanisms are limiting sensorimotor vocal learning.
在歌曲学习过程中，声音模式与导师所提供的听觉记忆相匹配，这是一个涉及感觉运动反馈的过程。鸟类的歌曲感觉运动学习和歌曲产生受一组相互连接的大脑核控制，即歌曲控制系统。在雄性斑马雀中，歌曲学习的感觉运动阶段的开始与大脑衍生神经营养因子 (BDNF) 在歌曲控制系统的一个特定部分（前脑核 HVC）中的增加相平行。我们在这里报告，HVC 中 BDNF-mRNA 的瞬时上调导致歌曲音节的最大程度复制。每个接受治疗的鸟类在运动学习方面都表现出与未经处理的斑马雀中所选最佳学习者相似的程度。由于在歌曲系统的 HVC 的目标区域中过表达 BDNF 并没有发现这种结果，因此 HVC 锚定的机制限制了感觉运动声音学习。
