大鼠整体和纵向切开的门静脉收缩。

Contractions of the whole and longitudinally cut rat's portal vein.

机构信息

Institute of Biophysics, Faculty of Medicine, University of Belgrade, 11129 Belgrade, Serbia.

出版信息

Comput Biol Med. 2013 Sep;43(9):1114-9. doi: 10.1016/j.compbiomed.2013.05.015. Epub 2013 Jun 2.

DOI:10.1016/j.compbiomed.2013.05.015

Abstract

To investigate the role of lateral interactions, we quantified spontaneous contractions of whole and longitudinally cut rat´s portal vein in vitro. The disruption of the wall had no effect on basic frequency determined from spectra and complexity index (CI) calculated by multiscale entropy analysis. Endothelium was disrupted and nonfunctional in all samples. Considering amplitude, frequency and CI we identified two modes of contractions. Neither mode of contractions nor the effect of aminopyridine (4-AP) depended on the integrity of the wall. We concluded that contractions in vitro originate in smooth muscle cells without involvement of the endothelium and lateral interactions.

摘要

为了研究侧向相互作用的作用，我们定量分析了整体和纵向切割的大鼠门静脉在体外的自发收缩。破坏血管壁对频谱确定的基本频率和多尺度熵分析计算的复杂度指数（CI）没有影响。所有样本的内皮均被破坏且失去功能。考虑到振幅、频率和 CI，我们确定了两种收缩模式。无论是收缩模式还是氨甲酰吡啶（4-AP）的作用都不依赖于血管壁的完整性。我们得出结论，体外收缩起源于平滑肌细胞，而不涉及内皮细胞和侧向相互作用。