Andreoulakis E, Hyphantis T, Kandylis D, Iacovides A
3 Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Hippokratia. 2012 Jul;16(3):205-14.
Although the prevalence of a mental disorder, in general, in patients with diabetes mellitus is regarded to be comparable to the general population, an increased prevalence of depressive disorders, often comorbid with anxiety, has been reported in patients with diabetes mellitus. The co-occurrence of depression in diabetes is attributed to a variety of factors, including the psychological and psychosocial impact of the disease, a potential common genetic susceptibility and common pathophysiological abnormalities involving neuroimmunological and neuroendocrinical pathways, as well as microvascular brain lesions due to diabetes mellitus. However, issues concerning pathogenesis and causality of this high co-occurrence are not fully determined yet. Still, the presence of depression in patients with diabetes mellitus is of vast importance, as it is usually associated with poor disease control, adverse health outcomes and quality of life impairment. This article aims to provide a comprehensive review of epidemiological findings, clinical considerations and management strategies concerning depression in patients with diabetes mellitus.
尽管一般认为糖尿病患者中精神障碍的患病率与普通人群相当，但据报道，糖尿病患者中抑郁症的患病率有所增加，且常伴有焦虑症。糖尿病合并抑郁症归因于多种因素，包括疾病的心理和社会心理影响、潜在的共同遗传易感性以及涉及神经免疫和神经内分泌途径的共同病理生理异常，以及糖尿病引起的微血管脑病变。然而，关于这种高共病率的发病机制和因果关系问题尚未完全明确。尽管如此，糖尿病患者中抑郁症的存在非常重要，因为它通常与疾病控制不佳、不良健康后果和生活质量受损有关。本文旨在对糖尿病患者抑郁症的流行病学研究结果、临床考量和管理策略进行全面综述。
