心肌：机械活动的数学建模与机械化学解偶联建模

Heart muscle: mathematical modelling of the mechanical activity and modelling of mechanochemical uncoupling.

作者信息

Katsnelson L B, Markhasin V S

机构信息

Laboratory of Biophysics, Institute of Industrial Hygiene and Occupational Diseases, Sverdlovsk, USSR.

出版信息

Gen Physiol Biophys. 1990 Jun;9(3):219-43.

PMID:2394370

Abstract

A mechanical model of heart muscle is proposed which includes rheological equations and equations for Ca-troponin interaction, for the dependences of the number of myosin cross-bridges on the length of sarcomere and on the speed of motion. The main assumption of the model is the dependence of the troponin affinity to calcium ions on the number of myosin cross-bridges attached. The model successfully imitates isometric and isotonic contractions, the "length-force" relationships, load-dependent relaxation, and the group of mechanical phenomena known as mechanochemical uncoupling.

摘要

提出了一种心肌力学模型，该模型包括流变方程以及钙肌钙蛋白相互作用的方程，用于描述肌球蛋白横桥数量与肌节长度和运动速度之间的依赖关系。该模型的主要假设是肌钙蛋白对钙离子的亲和力取决于附着的肌球蛋白横桥数量。该模型成功地模拟了等长收缩和等张收缩、“长度-力”关系、负荷依赖性舒张以及被称为机械化学解偶联的一组力学现象。