Nagpal A, Pritt B S, Lorenz E C, Amer H, Nasr S H, Cornell L D, Iqbal S, Wilhelm M P
Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Transpl Infect Dis. 2013 Oct;15(5):526-32. doi: 10.1111/tid.12119. Epub 2013 Aug 15.
Microsporidia are opportunistic pathogens that usually cause a limited disease in the gastrointestinal tract. Occasionally, they can cause disseminated disease. In solid organ transplant recipients, disseminated disease has been reported only rarely. We describe a 68-year-old woman who presented with fever, cough, and acute kidney injury 6 months after kidney transplantation. Dissemination was confirmed by identification of microsporidial spores in urine and bronchoalveolar lavage fluid. Polymerase chain reaction analysis identified the species as Encephalitozoon cuniculi.
微孢子虫是机会性致病原,通常在胃肠道引起局限性疾病。偶尔,它们可导致播散性疾病。在实体器官移植受者中,播散性疾病仅被罕见报道。我们描述了一名68岁女性,在肾移植6个月后出现发热、咳嗽和急性肾损伤。通过在尿液和支气管肺泡灌洗液中鉴定出微孢子虫孢子证实了播散。聚合酶链反应分析确定该物种为兔脑炎微孢子虫。