一例 IgD 型骨髓瘤代表了先前诊断为 IgA-λ 型骨髓瘤患者中漏检的双克隆副蛋白血症或同种型转换。
A case of IgD myeloma representing a missed biclonal paraproteinemia or isotype switch in a patient previously diagnosed with IgA-lambda myeloma.
机构信息
Mount Sinai Hospital, Dept of Pathology, Gustave L Levy Place, Box 1194, New York, NY 10128, USA.
出版信息
Clin Chim Acta. 2013 Oct 21;425:233-5. doi: 10.1016/j.cca.2013.08.004. Epub 2013 Aug 13.
BACKGROUND
Multiple myeloma is a clonal plasma cell neoplasm that is identified in the laboratory by a presence of a monoclonal immunoglobulin or increased plasma light chain levels.
METHODS
The most commonly identified and tested immunoglobulins are IgA, IgG and IgM.
RESULTS
Rare cases of multiple myeloma present with monoclonal IgD and IgE paraproteins.
CONCLUSION
We present a case of IgD myeloma diagnosed in a patient who had achieved partial remission from a previously diagnosed IgA myeloma, possibly representing a missed biclonal paraproteinemia or isotype switch after treatment.
背景
多发性骨髓瘤是一种克隆性浆细胞肿瘤，在实验室中通过存在单克隆免疫球蛋白或增加的血浆轻链水平来确定。
方法
最常识别和测试的免疫球蛋白是 IgA、IgG 和 IgM。
结果
罕见的多发性骨髓瘤病例表现为单克隆 IgD 和 IgE 副蛋白。
结论
我们报告了一例 IgD 骨髓瘤病例，该病例诊断于一名先前诊断为 IgA 骨髓瘤的患者，其部分缓解，可能代表治疗后错过的双克隆副蛋白血症或同种型转换。
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