常染色体显性多囊肾病（ADPKD）患儿的高血压

Hypertension in children with autosomal dominant polycystic kidney disease (ADPKD).

作者信息

Cadnapaphornchai Melissa A

机构信息

PKD Research Group, University of Colorado Anschutz Medical Campus, 13001 E. 17th Place, MSC283, Aurora, Colorado 80045, USA.

出版信息

Curr Hypertens Rev. 2013 Feb;9(1):21-6. doi: 10.2174/1573402111309010004.

DOI:10.2174/1573402111309010004

PMID:23971640

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease, affecting 1 in 1000 individuals. Previously termed "adult polycystic kidney disease", ADPKD is now known to have important clinical manifestations beginning early in life and even in utero. Hypertension is an important risk factor for progressive renal and cardiovascular disease in children with ADPKD and may signify irremediable organ injury. The purpose of this article is to review current knowledge and treatment strategies in hypertension associated with pediatric ADPKD.

摘要

常染色体显性多囊肾病（ADPKD）是最常见的遗传性肾病，发病率为千分之一。ADPKD以前被称为“成人多囊肾病”，现在已知在生命早期甚至子宫内就有重要的临床表现。高血压是ADPKD患儿发生进行性肾脏和心血管疾病的重要危险因素，可能意味着不可挽回的器官损伤。本文旨在综述小儿ADPKD相关高血压的现有知识和治疗策略。